John Wayne Casserole

This hearty Southwestern-inspired casserole delivers bold flavor in every layer, making it a standout dish for nights when you want something satisfying and full of character. With its combination of seasoned ground beef, vibrant peppers, and a creamy, cheesy topping, this recipe brings together classic comfort with a lively Tex-Mex twist. The biscuit base adds a warm, sturdy foundation that absorbs the flavors above it, creating a balanced and deeply comforting meal.

The beauty of this casserole lies in its approachable preparation. While the biscuit layer pre-bakes, the beef mixture comes together quickly on the stovetop, filling the kitchen with the aromas of onions, peppers, and taco spices. The creamy middle layer—made with sour cream or mayonnaise—melts into the beef as it bakes, keeping the casserole moist and adding a gentle richness that complements the savory filling.

Cheese plays a starring role here, offering both flavor and texture. A blend of cheddar and Monterey Jack melts into a bubbling, golden crown that contrasts beautifully with the hearty layers below. Once baked, the casserole slices cleanly, making it ideal for serving family-style or bringing to gatherings where you want to offer something warm, filling, and undeniably crowd-pleasing.

This dish is versatile enough to enjoy on its own, but it also pairs wonderfully with simple sides like a fresh green salad, black beans, or cilantro-lime rice. Its blend of comfort and bold Southwest flair makes it a recipe you will return to whenever you crave something robust and full of personality.

Servings and Timing

Servings: 6–8
Prep Time: 15 minutes
Cook Time: 35–40 minutes
Total Time: 50–55 minutes

Ingredients

• 1 lb ground beef
• 1 packet taco seasoning
• 1 cup chopped onions
• 1 cup chopped bell peppers (red and green)
• 1 can (10 oz) diced tomatoes with green chiles, drained
• 2 cups shredded cheddar cheese
• 1 cup shredded Monterey Jack
• 1 cup mayonnaise or sour cream
• 2 cups biscuit mix (such as Bisquick)
• 1 cup water

Instructions:

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